National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Clonidine

Synonyms

Catapres-TTS

clonidine

Clonidine

CLONIDINE

N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine

Definitions

An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C380

ALT_DEFINITION

The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist.

CAS_Registry

4205-90-7

CHEBI_ID

CHEBI:46631

CHEBI:3757

CHEBI:46632

Chemical_Formula

C9H9Cl2N3

code

C380

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.

FDA_UNII_Code

MN3L5RMN02

FULL_SYN

Catapres-TTS

clonidine

Clonidine

CLONIDINE

N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47979

label

Clonidine

Legacy_Concept_Name

Clonidine

PDQ_Closed_Trial_Search_ID

41228

PDQ_Open_Trial_Search_ID

41228

Preferred_Name

Clonidine

prefixIRI

ncit:C380

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0009014

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29709

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http://data.bnf.fr/ark:/12148/cb122666302 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/LNC/LP32548-7 LOINC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Clonidine APAONTO LOOM
http://purl.bioontology.org/ontology/LNC/LP14987-9 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4017850 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/1549-3722 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/C02AC01 ATC LOOM
http://purl.bioontology.org/ontology/SNMI/C-81130 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003000 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006193 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006193 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006193 DMTO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002290 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372805007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146207 NDFRT LOOM
http://doe-generated-ontology.com/OntoAD#C0009014 ONTOAD LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146207 OCVDAE LOOM
http://purl.bioontology.org/ontology/UATC/S01EA04 ATC LOOM
http://stirdf.jst.go.jp/id/200907069996732002 IOBC LOOM
http://stirdf.jst.go.jp/id/200907069996732002 IOBC LOOM
http://stirdf.jst.go.jp/id/200907069996732002 IOBC LOOM
http://stirdf.jst.go.jp/id/200907069996732002 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/x01Cz RCD LOOM
http://id.loc.gov/authorities/subjects/sh85027121 FAST-TOPICAL LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.436.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D003000 MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006190 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006190 DMTO LOOM
http://www.co-ode.org/ontologies/galen#Clonidine GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_46631 NIFSTD LOOM
http://www.drugbank.ca/drugs/DB00575 FTC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041228 PDQ LOOM
http://purl.bioontology.org/ontology/NDDF/004495 NDDF LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#clonidine SDO LOOM
http://purl.jp/bio/4/id/200906098150249577 IOBC LOOM
http://purl.jp/bio/4/id/200906098150249577 IOBC LOOM
http://purl.jp/bio/4/id/200906098150249577 IOBC LOOM
http://purl.jp/bio/4/id/200906098150249577 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/N02CX02 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/2599 RXNORM LOOM