National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Sulfasalazine
Synonyms

Sulfasalazine

2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic Acid

Sulphasalazine

Salazosulfapyridine

SULFASALAZINE

Azulfidine
Definitions

A synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and salicylic acid, by a mechanism that is not clear. It appears inhibit cyclooxygenase and prostaglandin production and is used in the management of inflammatory bowel diseases. (NCI04)
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29469
CAS_Registry

599-79-1
CHEBI_ID

CHEBI:9334
Chemical_Formula

C18H14N4O5S
code

C29469
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

A synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and salicylic acid, by a mechanism that is not clear. It appears inhibit cyclooxygenase and prostaglandin production and is used in the management of inflammatory bowel diseases. (NCI04)
Display_Name

Sulfasalazine
FDA_UNII_Code

3XC8GUZ6CB
FULL_SYN

Sulfasalazine

2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic Acid

Sulphasalazine

Salazosulfapyridine

SULFASALAZINE

Azulfidine
label

Sulfasalazine
Legacy Concept Name

Sulfasalazine
NCI_Drug_Dictionary_ID

685032
NSC Number

203730

667219
PDQ_Closed_Trial_Search_ID

685032
PDQ_Open_Trial_Search_ID

685032
Preferred_Name

Sulfasalazine
prefixIRI

Thesaurus:C29469
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0036078
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C257
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http://purl.bioontology.org/ontology/ATC/A07EC01 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146249 NDFRT LOOM
http://purl.obolibrary.org/obo/ARO_3000698 ARO LOOM
http://purl.bioontology.org/ontology/NDDF/002832 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0036078 OCHV LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000685032 PDQ LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015960 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.730 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/9524 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C29469 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387248006 SNOMEDCT LOOM
http://www.gamuts.net/entity#sulfasalazine GAMUTS LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_9334 ODNAE LOOM
http://purl.obolibrary.org/obo/OMIT_0013365 OMIT LOOM
http://purl.obolibrary.org/obo/MESH_D012460 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060449 LOINC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146249 ODAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.730 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11000 OCHV LOOM
https://go.drugbank.com/drugs/DB00795 MDM LOOM
http://purl.bioontology.org/ontology/SNMI/C-55960 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D012460 MESH LOOM
http://www.drugbank.ca/drugs/DB00795 FTC LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00470 COID LOOM
http://bmi.utah.edu/ontologies/peontology/C0036078 RAO LOOM
http://purl.bioontology.org/ontology/VANDF/4017897 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D012460 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP18088-2 LOINC LOOM