loading...| Preferred Name |
Oxycodone |
|
| Synonyms |
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone SR OXYCODONE Oxycodone |
|
| Definitions |
A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29309 |
|
| CAS_Registry |
76-42-6 |
|
| CHEBI_ID |
CHEBI:7852 |
|
| Chemical_Formula |
C18H21NO4 |
|
| code |
C29309 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. |
|
| Display_Name |
Oxycodone |
|
| FDA_UNII_Code |
CD35PMG570 |
|
| FULL_SYN |
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone SR OXYCODONE Oxycodone |
|
| Has_Salt_Form | ||
| label |
Oxycodone |
|
| Legacy Concept Name |
Oxycodone |
|
| NSC Number |
19043 |
|
| Preferred_Name |
Oxycodone |
|
| prefixIRI |
Thesaurus:C29309 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0030049 |
|
| subClassOf |