National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Azathioprine

Synonyms

AZTP

Azathioprine

AZATHIOPRINE

6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine

AZA

Definitions

A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C290

CAS_Registry

446-86-6

CHEBI_ID

CHEBI:2948

Chemical_Formula

C9H7N7O2S

code

C290

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

FDA_UNII_Code

MRK240IY2L

FULL_SYN

AZTP

Azathioprine

AZATHIOPRINE

6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine

AZA

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961

label

Azathioprine

Legacy_Concept_Name

Azathioprine

NSC_Code

39084

Preferred_Name

Azathioprine

prefixIRI

ncit:C290

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0004482

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1556

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001379 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/2910-8851 CRISP LOOM
http://www.co-ode.org/ontologies/galen#Azathioprine GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.900.111 RH-MESH LOOM
http://www.semanticweb.org/dellvostro3750/ontologies/2018/2/untitled-ontology-10#azathioprine HP_O LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_2948 EFO LOOM
http://purl.bioontology.org/ontology/RXNORM/1256 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP18898-4 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006794 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.534.090 RH-MESH LOOM
http://scai.fraunhofer.de/MSOntology#Azathioprine MSO LOOM
http://bmi.utah.edu/ontologies/peontology/C0004482 RAO LOOM
http://www.drugbank.ca/drugs/DB00993 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147069 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372574004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4018766 VANDF LOOM
http://purl.jp/bio/4/id/200906096730452725 IOBC LOOM
http://purl.jp/bio/4/id/200906096730452725 IOBC LOOM
http://purl.jp/bio/4/id/200906096730452725 IOBC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004940 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004940 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004940 DMTO LOOM
http://stirdf.jst.go.jp/id/200907029553878720 IOBC LOOM
http://stirdf.jst.go.jp/id/200907029553878720 IOBC LOOM
http://stirdf.jst.go.jp/id/200907029553878720 IOBC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0004482 HFO LOOM
http://purl.bioontology.org/ontology/RCD/x02MI RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.759.111 RH-MESH LOOM
http://www.genomic-cds.org/ont/genomic-cds.owl#Azathioprine GENE-CDS LOOM
http://purl.bioontology.org/ontology/SNMI/C-B7040 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D001379 MESH LOOM
http://purl.bioontology.org/ontology/UATC/L04AX01 ATC LOOM