loading...| Preferred Name |
Azathioprine |
| Synonyms |
AZTP Azathioprine AZATHIOPRINE 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZA |
| Definitions |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C290 |
| CAS_Registry |
446-86-6 |
| CHEBI_ID |
CHEBI:2948 |
| Chemical_Formula |
C9H7N7O2S |
| code |
C290 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 |
| Contributing_Source |
FDA |
| DEFINITION |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
| FDA_UNII_Code |
MRK240IY2L |
| FULL_SYN |
AZTP Azathioprine AZATHIOPRINE 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZA |
| Has_Salt_Form | |
| label |
Azathioprine |
| Legacy_Concept_Name |
Azathioprine |
| NSC_Code |
39084 |
| Preferred_Name |
Azathioprine |
| prefixIRI |
ncit:C290 |
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
| UMLS_CUI |
C0004482 |
| subClassOf |