Preferred Name |
Azathioprine |
Synonyms |
AZTP Azathioprine AZATHIOPRINE 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZA |
Definitions |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C290 |
CAS_Registry |
446-86-6 |
CHEBI_ID |
CHEBI:2948 |
Chemical_Formula |
C9H7N7O2S |
code |
C290 |
Concept_In_Subset | |
Contributing_Source |
FDA |
DEFINITION |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
FDA_UNII_Code |
MRK240IY2L |
FULL_SYN |
AZTP Azathioprine AZATHIOPRINE 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZA |
Has_Salt_Form | |
label |
Azathioprine |
Legacy_Concept_Name |
Azathioprine |
NSC_Code |
39084 |
Preferred_Name |
Azathioprine |
prefixIRI |
ncit:C290 |
Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
UMLS_CUI |
C0004482 |
subClassOf |