National Cancer Institute Thesaurus

Last uploaded: December 30, 2019
Preferred Name

Ritonavir

Synonyms

RIT

ritonavir

RITONAVIR

Ritonavir

Norvir

Definitions

A peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1609

ALT_DEFINITION

A drug used to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Ritonavir blocks the ability of HIV to make copies of itself and may block the growth of cancer cells. It is a type of anti-HIV agent and a type of protease inhibitor.

CAS_Registry

155213-67-5

CHEBI_ID

CHEBI:45409

Chemical_Formula

C37H48N6O5S2

code

C1609

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.

Display_Name

Ritonavir

FDA_UNII_Code

O3J8G9O825

FULL_SYN

RIT

ritonavir

RITONAVIR

Ritonavir

Norvir

label

Ritonavir

Legacy_Concept_Name

Ritonavir

NSC_Code

693184

PDQ_Closed_Trial_Search_ID

42665

PDQ_Open_Trial_Search_ID

42665

Preferred_Name

Ritonavir

prefixIRI

ncit:C1609

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0292818

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97366

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http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.bioontology.org/ontology/LNC/LP21314-7 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4020963 VANDF LOOM
http://purl.obolibrary.org/obo/dinto_DB00503 DINTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148436 NDFRT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005535 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005535 DMTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004487 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004487 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004487 DMTO LOOM
http://stirdf.jst.go.jp/id/200907009848165600 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.708.653 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005602 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005602 DMTO LOOM
http://purl.bioontology.org/ontology/RXNORM/85762 RXNORM LOOM
http://purl.bioontology.org/ontology/UATC/J05AE03 ATC LOOM
http://www.co-ode.org/ontologies/galen#Ritonavir GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019438 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/005554 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 HUPSON LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_45409 NIFSTD LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148436 ODAE LOOM
http://purl.bioontology.org/ontology/MESH/D019438 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.675.653 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/4009-0059 CRISP LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386896009 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906077477894860 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/eiF.. RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0292818 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#27775 OCHV LOOM
http://bioportal/bioontology.org/ontologies/HIVO0004#OWLClass_00000002947544878399 HIVO004 LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013855 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042665 PDQ LOOM