loading...| Preferred Name |
Oxaliplatin |
|
| Synonyms |
Oxalatoplatinum [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum Oxaliplatin oxaliplatin oxalato (1R,2R-cyclohexanediamine)platinum(II) Diaminocyclohexane Oxalatoplatinum trans-l DACH oxalatoplatinum [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum Oxalatoplatin oxalato (trans-l-1,2-diaminocyclohexane)platinum(II) OXALIPLATIN trans-l diaminocyclohexane oxalatoplatinum 1-OHP Ai Heng Aiheng DACPLAT Dacotin Dacplat ELOXATIN Eloxatin Eloxatine JM-83 RP 54780 RP-54780 SR-96669 |
|
| Definitions |
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1181 |
|
| Accepted_Therapeutic_Use_For |
Metastatic colorectal cancer; ovarian cancer |
|
| ALT_DEFINITION |
A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound. |
|
| CAS_Registry |
61825-94-3 |
|
| CHEBI_ID |
CHEBI:31941 |
|
| Chemical_Formula |
C8H14N2O4Pt |
|
| code |
C1181 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04) |
|
| Display_Name |
Oxaliplatin |
|
| FDA_UNII_Code |
04ZR38536J |
|
| FULL_SYN |
Oxalatoplatinum [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum Oxaliplatin oxaliplatin oxalato (1R,2R-cyclohexanediamine)platinum(II) Diaminocyclohexane Oxalatoplatinum trans-l DACH oxalatoplatinum [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum Oxalatoplatin oxalato (trans-l-1,2-diaminocyclohexane)platinum(II) OXALIPLATIN trans-l diaminocyclohexane oxalatoplatinum 1-OHP Ai Heng Aiheng DACPLAT Dacotin Dacplat ELOXATIN Eloxatin Eloxatine JM-83 RP 54780 RP-54780 SR-96669 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Oxaliplatin |
|
| Legacy Concept Name |
Oxaliplatin |
|
| Maps_To |
Oxaliplatin |
|
| NCI_Drug_Dictionary_ID |
42374 |
|
| NSC Number |
266046 |
|
| PDQ_Closed_Trial_Search_ID |
42374 |
|
| PDQ_Open_Trial_Search_ID |
42374 |
|
| Preferred_Name |
Oxaliplatin |
|
| prefixIRI |
Thesaurus:C1181 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0069717 |
|
| subClassOf |