loading...| Preferred Name |
Vancomycin |
|
| Synonyms |
VANCOMYCIN Vancomycin vancomycin |
|
| Definitions |
A branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C925 |
|
| ALT_DEFINITION |
An antibiotic drug used to fight resistant bacterial infections. |
|
| CAS_Registry |
1404-90-6 |
|
| CHEBI_ID |
CHEBI:28001 |
|
| Chemical_Formula |
C66H75Cl2N9O24 |
|
| code |
C925 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis. |
|
| Display_Name |
Vancomycin |
|
| FDA_UNII_Code |
6Q205EH1VU |
|
| FULL_SYN |
VANCOMYCIN Vancomycin vancomycin |
|
| Has_Salt_Form | ||
| label |
Vancomycin |
|
| Legacy Concept Name |
Vancomycin |
|
| NCI_Drug_Dictionary_ID |
39731 |
|
| PDQ_Closed_Trial_Search_ID |
39731 |
|
| PDQ_Open_Trial_Search_ID |
39731 |
|
| Preferred_Name |
Vancomycin |
|
| prefixIRI |
Thesaurus:C925 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0042313 |
|
| subClassOf |