loading...| Preferred Name |
Mycophenolic Acid |
|
| Synonyms |
MYCOPHENOLIC ACID Acide mycophenolique 4-Hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)- Lilly-68618 Acido micofenolico Acidum mycophenolicum Mycophenolic Acid 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)- Ly 68618 MPA Myfortic |
|
| Definitions |
An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C673 |
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| Accepted_Therapeutic_Use_For |
Prophylaxis of organ rejection after allogenic renal; cardiac; or hepatic transplants; psoriasis |
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| CAS_Registry |
24280-93-1 483-60-3 |
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| CHEBI_ID |
CHEBI:168396 |
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| Chemical_Formula |
C17H20O6 |
|
| code |
C673 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04) |
|
| Display_Name |
Mycophenolic Acid |
|
| FDA_UNII_Code |
HU9DX48N0T |
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| FULL_SYN |
MYCOPHENOLIC ACID Acide mycophenolique 4-Hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)- Lilly-68618 Acido micofenolico Acidum mycophenolicum Mycophenolic Acid 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)- Ly 68618 MPA Myfortic |
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| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Mycophenolic Acid |
|
| Legacy Concept Name |
Mycophenolic_Acid |
|
| Maps_To |
Mycophenolic Acid |
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| NCI_Drug_Dictionary_ID |
732227 |
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| NSC Number |
129185 |
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| PDQ_Closed_Trial_Search_ID |
732227 |
|
| PDQ_Open_Trial_Search_ID |
732227 |
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| Preferred_Name |
Mycophenolic Acid |
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| prefixIRI |
Thesaurus:C673 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
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| UMLS_CUI |
C0026933 |
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| subClassOf |