loading...| Preferred Name |
Propoxyphene, (+/-)- |
|
| Synonyms |
DL-Propoxyphene Propoxyphene, (+/-)- PROPOXYPHENE, (+/-)- |
|
| Definitions |
A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61711 |
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| CAS_Registry |
2621-61-6 |
|
| Chemical_Formula |
C22H29NO2 |
|
| code |
C61711 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. |
|
| FDA_UNII_Code |
II2G62OV6F |
|
| FULL_SYN |
DL-Propoxyphene Propoxyphene, (+/-)- PROPOXYPHENE, (+/-)- |
|
| label |
Propoxyphene, (+/-)- |
|
| Legacy Concept Name |
DL-Propoxyphene |
|
| Preferred_Name |
Propoxyphene, (+/-)- |
|
| prefixIRI |
Thesaurus:C61711 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1880235 |
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| subClassOf |