loading...| Preferred Name |
Hydralazine Hydrochloride |
|
| Synonyms |
Hydralazine Hydrochloride HYDRALAZINE HYDROCHLORIDE Apresoline Apressin |
|
| Definitions |
The hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C551 |
|
| CAS_Registry |
304-20-1 |
|
| CHEBI_ID |
CHEBI:31672 |
|
| Chemical_Formula |
C8H8N4.HCl |
|
| code |
C551 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells. |
|
| Display_Name |
Hydralazine Hydrochloride |
|
| FDA_UNII_Code |
FD171B778Y |
|
| FULL_SYN |
Hydralazine Hydrochloride HYDRALAZINE HYDROCHLORIDE Apresoline Apressin |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Hydralazine Hydrochloride |
|
| Legacy Concept Name |
Hydralazine |
|
| Maps_To |
Hydralazine Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
41835 |
|
| NSC Number |
89394 |
|
| PDQ_Closed_Trial_Search_ID |
41835 |
|
| PDQ_Open_Trial_Search_ID |
41835 |
|
| Preferred_Name |
Hydralazine Hydrochloride |
|
| prefixIRI |
Thesaurus:C551 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0699178 |
|
| subClassOf |