loading...| Preferred Name |
Pentobarbital Sodium |
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| Synonyms |
Pentobarbital Sodium Barbituric Acid, 5-ethyl-5-(1-methylbutyl)-,Sodium Salt Mebumal Sodium 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-Ethyl-5-(1-methylbutyl), Monosodium Salt PENTOBARBITAL SODIUM Barpental Nembutal Pental |
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| Definitions |
The sodium salt of pentobarbital, a short-acting barbituric acid derivative with central nervous system (CNS) depressant property. Pentobarbital sodium binds to the gamma-aminobutyric acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through receptor channels and potentiation of GABA-induced increases in chloride conductance. This enhances postsynaptic responses to the inhibitory actions of GABA and causes CNS depression. In addition, this agent inhibits glutamate induced nerve depolarization and depresses voltage-activated calcium currents. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47662 |
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| CAS_Registry |
57-33-0 |
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| Chemical_Formula |
C11H17N2O3.Na |
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| code |
C47662 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The sodium salt of pentobarbital, a short-acting barbituric acid derivative with central nervous system (CNS) depressant property. Pentobarbital sodium binds to the gamma-aminobutyric acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through receptor channels and potentiation of GABA-induced increases in chloride conductance. This enhances postsynaptic responses to the inhibitory actions of GABA and causes CNS depression. In addition, this agent inhibits glutamate induced nerve depolarization and depresses voltage-activated calcium currents. |
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| FDA_UNII_Code |
NJJ0475N0S |
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| FULL_SYN |
Pentobarbital Sodium Barbituric Acid, 5-ethyl-5-(1-methylbutyl)-,Sodium Salt Mebumal Sodium 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-Ethyl-5-(1-methylbutyl), Monosodium Salt PENTOBARBITAL SODIUM Barpental Nembutal Pental |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Pentobarbital Sodium |
|
| Legacy Concept Name |
Pentobarbital_Sodium |
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| NSC Number |
10816 |
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| Preferred_Name |
Pentobarbital Sodium |
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| prefixIRI |
Thesaurus:C47662 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700349 |
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| subClassOf |