loading...| Preferred Name |
Aprotinin |
|
| Synonyms |
TachoComb H Trypsin Inhibitor, Pancreatic Basic Bayer-A-128 Aprotinin Bovine APROTININ Aprotinin RP-9921 Riker-52g Trasylol |
|
| Definitions |
A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47402 |
|
| CAS_Registry |
11005-72-4 |
|
| Chemical_Formula |
C284H432N84O79S7 |
|
| code |
C47402 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. |
|
| Display_Name |
Aprotinin |
|
| FDA_UNII_Code |
04XPW8C0FL |
|
| FULL_SYN |
TachoComb H Trypsin Inhibitor, Pancreatic Basic Bayer-A-128 Aprotinin Bovine APROTININ Aprotinin RP-9921 Riker-52g Trasylol |
|
| label |
Aprotinin |
|
| Legacy Concept Name |
Aprotinin_Bovine |
|
| NCI_Drug_Dictionary_ID |
480388 |
|
| PDQ_Closed_Trial_Search_ID |
480388 |
|
| PDQ_Open_Trial_Search_ID |
480388 |
|
| Preferred_Name |
Aprotinin |
|
| prefixIRI |
Thesaurus:C47402 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0003641 |
|
| subClassOf |