Preferred Name |
Insulin Lispro |
|
Synonyms |
INSULIN LISPRO Insulin Lispro Humalog |
|
Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29123 |
|
CAS_Registry |
133107-64-9 |
|
Chemical_Formula |
C257H383N65O77S6 |
|
code |
C29123 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. (NCI04) |
|
FDA_UNII_Code |
GFX7QIS1II |
|
FULL_SYN |
INSULIN LISPRO Insulin Lispro Humalog |
|
label |
Insulin Lispro |
|
Legacy Concept Name |
Lispo_Insulin |
|
Preferred_Name |
Insulin Lispro |
|
prefixIRI |
Thesaurus:C29123 |
|
Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
UMLS_CUI |
C0293359 |
|
subClassOf |