loading...| Preferred Name |
Bumetanide |
|
| Synonyms |
BUMETANIDE Bumetanide Bumex |
|
| Definitions |
A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28875 |
|
| CAS_Registry |
28395-03-1 |
|
| CHEBI_ID |
CHEBI:3213 |
|
| Chemical_Formula |
C17H20N2O5S |
|
| code |
C28875 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. |
|
| Display_Name |
Bumetanide |
|
| FDA_UNII_Code |
0Y2S3XUQ5H |
|
| FULL_SYN |
BUMETANIDE Bumetanide Bumex |
|
| label |
Bumetanide |
|
| Legacy Concept Name |
Bumetanide |
|
| NCI_Drug_Dictionary_ID |
788832 |
|
| PDQ_Closed_Trial_Search_ID |
788832 |
|
| PDQ_Open_Trial_Search_ID |
788832 |
|
| Preferred_Name |
Bumetanide |
|
| prefixIRI |
Thesaurus:C28875 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0701009 |
|
| subClassOf |