loading...| Preferred Name |
Proteasome Inhibitor |
|
| Synonyms |
proteasome inhibitor Proteasome Inhibitor |
|
| Definitions |
Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2160 |
|
| ALT_DEFINITION |
A drug that blocks the action of proteasomes. A proteasome is a large protein complex that helps destroy other cellular proteins when they are no longer needed. Proteasome inhibitors are being studied in the treatment of cancer. |
|
| CHEBI_ID |
CHEBI:52726 |
|
| code |
C2160 |
|
| DEFINITION |
Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. |
|
| FULL_SYN |
proteasome inhibitor Proteasome Inhibitor |
|
| label |
Proteasome Inhibitor |
|
| Legacy Concept Name |
Proteasome_Inhibitor |
|
| Preferred_Name |
Proteasome Inhibitor |
|
| prefixIRI |
Thesaurus:C2160 |
|
| Semantic_Type |
Chemical Viewed Functionally |
|
| UMLS_CUI |
C1443643 |
|
| subClassOf |