loading...| Preferred Name |
Acridine |
|
| Synonyms |
ACRIDINE Acridine |
|
| Definitions |
A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C203 |
|
| CAS_Registry |
260-94-6 |
|
| CHEBI_ID |
CHEBI:36420 |
|
| code |
C203 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death. |
|
| FDA_UNII_Code |
42NI1P5Q1X |
|
| FULL_SYN |
ACRIDINE Acridine |
|
| Is_Value_For_GDC_Property | ||
| label |
Acridine |
|
| Legacy Concept Name |
Acridine |
|
| Maps_To |
Acridine |
|
| Preferred_Name |
Acridine |
|
| prefixIRI |
Thesaurus:C203 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0001186 |
|
| subClassOf |