loading...| Preferred Name |
Vascular Endothelial Growth Factor Receptor |
|
| Synonyms |
Receptor, Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Receptor VEGFR |
|
| Definitions |
There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17293 |
|
| code |
C17293 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor. |
|
| Display_Name |
Vascular Endothelial Growth Factor Receptor |
|
| FULL_SYN |
Receptor, Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Receptor VEGFR |
|
| label |
Vascular Endothelial Growth Factor Receptor |
|
| Legacy Concept Name |
Vascular_Endothelial_Growth_Factor_Receptor |
|
| Preferred_Name |
Vascular Endothelial Growth Factor Receptor |
|
| prefixIRI |
Thesaurus:C17293 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme Receptor |
|
| UMLS_CUI |
C0148199 |
|
| subClassOf |