loading...| Preferred Name |
Tubulin |
|
| Synonyms |
Tubulin tubulin |
|
| Definitions |
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17219 |
|
| ALT_DEFINITION |
One of a group of proteins found in high levels in the cell cytoplasm (fluid inside a cell but outside the cell's nucleus). Tubulins are the building blocks of microtubules (narrow, hollow tubes inside a cell), which are involved in cell division and cell movement. Certain anticancer drugs bind to and block the formation or function of tubulins, which may block cell division. |
|
| code |
C17219 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink) |
|
| Display_Name |
Tubulin |
|
| FULL_SYN |
Tubulin tubulin |
|
| label |
Tubulin |
|
| Legacy Concept Name |
Tubulin |
|
| Preferred_Name |
Tubulin |
|
| prefixIRI |
Thesaurus:C17219 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| UMLS_CUI |
C0041348 |
|
| subClassOf |