loading...| Preferred Name |
Transformation |
|
| Synonyms |
Transformation Cell Transformation Transforming Cellular Transformation transformation Transformed |
|
| Definitions |
The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17212 |
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| ALT_DEFINITION |
In medicine, the change that a normal cell undergoes as it becomes malignant. |
|
| code |
C17212 |
|
| DEFINITION |
The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. |
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| FULL_SYN |
Transformation Cell Transformation Transforming Cellular Transformation transformation Transformed |
|
| label |
Transformation |
|
| Legacy Concept Name |
Transformation |
|
| Preferred_Name |
Transformation |
|
| prefixIRI |
Thesaurus:C17212 |
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| Semantic_Type |
Pathologic Function |
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| UMLS_CUI |
C1510411 |
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| subClassOf |