Preferred Name |
Sumatriptan |
|
Synonyms |
Sumatriptan SUMATRIPTAN |
|
Definitions |
A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1240 |
|
CAS_Registry |
103628-46-2 |
|
CHEBI_ID |
CHEBI:10650 |
|
Chemical_Formula |
C14H21N3O2S |
|
code |
C1240 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve. |
|
FDA_UNII_Code |
8R78F6L9VO |
|
FULL_SYN |
Sumatriptan SUMATRIPTAN |
|
Has_Salt_Form | ||
label |
Sumatriptan |
|
Legacy Concept Name |
Sumatriptan |
|
Preferred_Name |
Sumatriptan |
|
prefixIRI |
Thesaurus:C1240 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0075632 |
|
subClassOf |