loading...| Preferred Name |
Genistein |
|
| Synonyms |
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 4',5, 7-Trihydroxyisoflavone 4',5,7-Trihydroxyisoflavone GENISTEIN Genestein Genistein Genisteol Prunetol genistein |
|
| Definitions |
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1113 |
|
| ALT_DEFINITION |
An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer. An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring. |
|
| CAS_Registry |
446-72-0 |
|
| CHEBI_ID |
CHEBI:28088 |
|
| Chemical_Formula |
C15H10O5 |
|
| code |
C1113 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CRCH CTRP FDA GDC |
|
| DEFINITION |
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04) |
|
| Display_Name |
Genistein |
|
| FDA_UNII_Code |
DH2M523P0H |
|
| FULL_SYN |
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 4',5, 7-Trihydroxyisoflavone 4',5,7-Trihydroxyisoflavone GENISTEIN Genestein Genistein Genisteol Prunetol genistein |
|
| Has_Target | ||
| INFOODS |
GNSTEIN |
|
| Is_Value_For_GDC_Property | ||
| label |
Genistein |
|
| Legacy Concept Name |
Genistein |
|
| Maps_To |
Genistein |
|
| NCI_Drug_Dictionary_ID |
43214 |
|
| NSC Number |
36586 |
|
| PDQ_Closed_Trial_Search_ID |
43214 |
|
| PDQ_Open_Trial_Search_ID |
43214 |
|
| Preferred_Name |
Genistein |
|
| prefixIRI |
Thesaurus:C1113 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0061202 |
|
| Unit |
mcg |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1742 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1821 |