loading...| Preferred Name |
diclofenac |
|
| Synonyms |
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid |
|
| Definitions |
A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. [url:http://purl.obolibrary.org/obo/NCIT_C28985] |
|
| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:03067 |
|
| definition |
A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. [url:http://purl.obolibrary.org/obo/NCIT_C28985] |
|
| label |
diclofenac |
|
| MIO_ID |
MIO:03067 |
|
| prefLabel |
diclofenac |
|
| reference |
CHEBI:47381 NCIT:C28985 UMLS:C0012091 |
|
| synonyms |
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:03044 |