Preferred Name |
labetalol |
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Synonyms |
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Definitions |
A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. [url:http://purl.obolibrary.org/obo/NCIT_C29146] |
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ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02650 |
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definition |
A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. [url:http://purl.obolibrary.org/obo/NCIT_C29146] |
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label |
labetalol |
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MIO_ID |
MIO:02650 |
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prefLabel |
labetalol |
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reference |
NCIT:C29146 CHEBI:6343 |
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subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02181 |