loading...| Preferred Name |
tirofiban |
|
| Synonyms |
aggrastat-TM MK-383 |
|
| Definitions |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time. [url:http://purl.obolibrary.org/obo/NCIT_C76405] |
|
| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02158 |
|
| definition |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time. [url:http://purl.obolibrary.org/obo/NCIT_C76405] |
|
| label |
tirofiban |
|
| MIO_ID |
MIO:02158 |
|
| prefLabel |
tirofiban |
|
| reference |
NCIT:C76405 UMLS:C0247025 CHEBI:9605 |
|
| synonyms |
aggrastat-TM MK-383 |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02155 http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01097 |