loading...| Preferred Name |
Oxaliplatin |
|
| Synonyms |
Oxaliplatin, (SP-4-2-(1R-trans))-isomer |
|
| Definitions |
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D000077150 |
|
| altLabel |
Oxaliplatin, (SP-4-2-(1R-trans))-isomer Oxaliplatine Eloxatine Oxaliplatin, (SP-4-3-(cis))-isomer 1,2-Diaminocyclohexane Platinum Oxalate Oxalato-(1,2-cyclohexanediamine)platinum II L-OHP Cpd 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II) Eloxatin Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1) 1,2 Diaminocyclohexane Platinum Oxalate ACT 078 ACT-078 Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) Oxaliplatin, (SP-4-2-(1S-trans))-isomer Platinum(II)-1,2-cyclohexanediamine Oxalate ACT078 |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C0284045 C0284044 C1135117 C0954915 C0069717 C0954917 |
|
| DC |
1 |
|
| definition |
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. |
|
| DX |
20190101 |
|
| HN |
2019 (1981) |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
61913-68-6 0 04ZR38536J 61758-77-8 |
|
| isa | ||
| LT |
TRD |
|
| Machine permutation |
2019; OXALIPLATIN was indexed under ORGANOPLATINUM COMPOUNDS 1981-2018 |
|
| Mapped from | ||
| MDA |
20180709 |
|
| MMR |
20190705 |
|
| MN |
D02.257.750 |
|
| notation |
D000077150 |
|
| PA |
D000970 |
|
| prefLabel |
Oxaliplatin |
|
| RR |
61758-77-8 ((SP-4-2-(1S-trans))-isomer) 61913-68-6 ((SP-4-3-(cis))-isomer) |
|
| TERMUI |
T000937039 T507589 T125549 T000937036 T000937040 T000937037 T000937033 T125550 T000962381 T000937043 T000937035 T000936956 T589357 T000937042 T000937038 T000937034 |
|
| TH |
US UK NL NLM (2020) NLM (2001) ES NLM (1981) USAN (19XX) INN (19XX) DE FDA SRS (2015) NLM (2011) FR |
|
| tui |
T109 T121 |
|
| subClassOf |