Preferred Name |
Microcephaly |
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Synonyms |
small cranium small calvarium Small head circumference Decreased size of skull Abnormally small cranium Abnormally small skull Reduced head circumference Decreased circumference of cranium Decreased size of cranium Small skull Decreased size of head Abnormally small head Small head |
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Definitions |
Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles, others by standard deviations. It is important to add an indication of how far below the normal standard the head circumference is if an accurate assessment of this can be made. Microcephaly is an absolute term. The term relative microcephaly can be used when the head size centile is less than the centile for height, for example, head size at the 3rd centile with height at the 75% for age and sex. On prenatal ultrasound, microcephaly is diagnosed if the head circumference or the biparietal diameter is more than three standard deviations below the mean. Microcephaly is divided into primary microcephaly, which is present at birth, and secondary microcephaly, which develops postnatally. The crucial difference between these groupings is that primary microcephaly is usually a static developmental anomaly, whereas secondary microcephaly indicates a progressive neurodegenerative condition Head circumference below 2 standard deviations below the mean for age and gender. |
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ID |
http://purl.obolibrary.org/obo/HP_0000252 |
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comment |
Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles, others by standard deviations. It is important to add an indication of how far below the normal standard the head circumference is if an accurate assessment of this can be made. Microcephaly is an absolute term. The term relative microcephaly can be used when the head size centile is less than the centile for height, for example, head size at the 3rd centile with height at the 75% for age and sex. On prenatal ultrasound, microcephaly is diagnosed if the head circumference or the biparietal diameter is more than three standard deviations below the mean. Microcephaly is divided into primary microcephaly, which is present at birth, and secondary microcephaly, which develops postnatally. The crucial difference between these groupings is that primary microcephaly is usually a static developmental anomaly, whereas secondary microcephaly indicates a progressive neurodegenerative condition |
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database_cross_reference |
UMLS:C4551563 SNOMEDCT_US:271611007 Fyler:4310 |
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definition |
Head circumference below 2 standard deviations below the mean for age and gender. |
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has_broad_synonym |
Small skull Decreased size of head Abnormally small head Small head |
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has_exact_synonym |
small cranium small calvarium Small head circumference Decreased size of skull Abnormally small cranium Abnormally small skull Reduced head circumference Decreased circumference of cranium Decreased size of cranium |
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label |
Microcephaly |
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prefixIRI |
HP:0000252 |
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prefLabel |
Microcephaly |
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subClassOf |