loading...| Preferred Name |
apical ectodermal ridge |
|
| Synonyms |
crista ectodermalis apicalis AER apical epidermal ridge |
|
| Definitions |
multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
|
| ID |
http://purl.obolibrary.org/obo/UBERON_0004356 |
|
| axiom_lost_from_external_ontology |
relationship loss: subclass proliferative region (TAO:0000098)[TAO] |
|
| curator note |
note that media, dorsal fins etc have AERs. |
|
| database_cross_reference |
http://en.wikipedia.org/wiki/Apical_ectodermal_ridge http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34109 http://linkedlifedata.com/resource/umls/id/C1516037 EMAPA:32744 ZFA:0001702 UMLS:C1516037 TAO:0002146 XAO:0004121 AAO:0010760 |
|
| definition |
multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
|
| depicted by |
http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg |
|
| developmentally_induced_by | ||
| external_definition |
Proliferative region that is part of the developing fin fold or fin.[TAO] Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO] |
|
| function_notes |
maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop |
|
| has exact synonym |
apical epidermal ridge |
|
| has_obo_namespace |
uberon |
|
| has_related_synonym |
crista ectodermalis apicalis AER |
|
| id |
UBERON:0004356 |
|
| imported from | ||
| in_subset |
http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim |
|
| label |
apical ectodermal ridge |
|
| notation |
UBERON:0004356 |
|
| part_of | ||
| prefLabel |
apical ectodermal ridge |
|
| taxon_notes |
The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold |
|
| treeView | ||
| subClassOf |