Preferred Name |
cyclosporin A |
|
Synonyms |
Cyclosporin A 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine] ciclosporin CC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C Cyclosporine Gengraf Neoral ciclosporina Antibiotic S 7481F1 Sandimmune InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1 ciclosporinum InChIKey=PMATZTZNYRCHOR-VJRYSDSKSA-N Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl) Ciclosporin C62H111N11O12 ciclosporine (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) |
|
Definitions |
A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_4031 |
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database_cross_reference |
CiteXplore:14621732 ChemIDplus:59865-13-3 CiteXplore:19282398 CiteXplore:11058832 CiteXplore:15613074 CiteXplore:18171316 CiteXplore:11529914 CiteXplore:17603747 CiteXplore:18790203 CiteXplore:17117422 CiteXplore:17192032 Wikipedia:Ciclosporin CiteXplore:12761440 CiteXplore:18259730 CiteXplore:12950728 CiteXplore:14743390 KEGG DRUG:D00184 CiteXplore:15383526 CiteXplore:15626898 CiteXplore:11370709 CiteXplore:18076075 Beilstein:3647785 CiteXplore:19589783 CiteXplore:11564166 Reaxys:3647785 CiteXplore:18597363 CiteXplore:11278005 CiteXplore:11080188 CiteXplore:17083576 CiteXplore:17220244 CiteXplore:11238591 CiteXplore:18931077 CiteXplore:16724420 CiteXplore:11676831 CiteXplore:18359899 CiteXplore:12021257 CiteXplore:16404634 CiteXplore:17265451 CiteXplore:14682659 CiteXplore:11406057 CiteXplore:11079273 CiteXplore:12050171 CiteXplore:12603598 CiteXplore:11870366 CiteXplore:11069928 CiteXplore:11493684 KEGG COMPOUND:C05086 CiteXplore:16372476 CiteXplore:11426833 CiteXplore:14521916 CiteXplore:15030555 CiteXplore:14672695 CiteXplore:15306697 CiteXplore:18975184 CiteXplore:15541012 CiteXplore:18818682 CiteXplore:17032751 CiteXplore:18299432 CiteXplore:16898534 CiteXplore:11315347 CiteXplore:18217899 CiteXplore:15711594 CiteXplore:18191430 CiteXplore:16801218 CiteXplore:15175101 CiteXplore:15657176 CiteXplore:14638917 CiteXplore:18583716 KEGG COMPOUND:59865-13-3 CiteXplore:11557554 CiteXplore:17229932 CiteXplore:11256490 Patent:US4117118 CiteXplore:15811524 DrugBank:DB00091 CiteXplore:15210365 CiteXplore:12929192 CiteXplore:17446460 CiteXplore:11442023 CiteXplore:1566062 CiteXplore:11481617 CiteXplore:15962181 |
|
definition |
A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. |
|
has_alternative_id |
CHEBI:63586 |
|
has_exact_synonym |
Cyclosporin A 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
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has_obo_namespace |
chebi_ontology |
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has_related_synonym |
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine] ciclosporin CC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C Cyclosporine Gengraf Neoral ciclosporina Antibiotic S 7481F1 Sandimmune InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1 ciclosporinum InChIKey=PMATZTZNYRCHOR-VJRYSDSKSA-N Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl) Ciclosporin C62H111N11O12 ciclosporine (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) |
|
id |
CHEBI:4031 |
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imported from | ||
label |
cyclosporin A |
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notation |
CHEBI:4031 |
|
prefixIRI |
CHEBI:4031 |
|
prefLabel |
cyclosporin A |
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subClassOf |