loading...| Preferred Name |
apical ectodermal ridge |
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| Synonyms |
crista ectodermalis apicalis AER apical epidermal ridge |
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| Definitions |
Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0004356 |
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| alternative label |
crista ectodermalis apicalis AER apical epidermal ridge |
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| capable of | ||
| capable of part of | ||
| curator note |
note that media, dorsal fins etc have AERs. |
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| database_cross_reference |
EMAPA:32744 AAO:0010760 TAO:0002146 NCIT:C34109 XAO:0004121 UMLS:C1516037 ZFA:0001702 Wikipedia:Apical_ectodermal_ridge |
|
| definition |
Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
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| depicted_by |
http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg |
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| depiction |
http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg |
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| developmentally induced by | ||
| functionally related to | ||
| has exact synonym |
apical epidermal ridge |
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| has_obo_namespace |
uberon |
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| has_related_synonym |
crista ectodermalis apicalis AER |
|
| id |
UBERON:0004356 |
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| in_subset | ||
| label |
apical ectodermal ridge |
|
| notation |
UBERON:0004356 |
|
| note |
Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
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| part_of | ||
| preferred label |
apical ectodermal ridge |
|
| prefLabel |
apical ectodermal ridge |
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| produces | ||
| textual definition |
Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
|
| treeView | ||
| UBPROP_0000001 |
Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO] Proliferative region that is part of the developing fin fold or fin.[TAO] |
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| UBPROP_0000002 |
relationship loss: subclass proliferative region (TAO:0000098)[TAO] |
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| UBPROP_0000008 |
The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold |
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| UBPROP_0000009 |
maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop |
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| subClassOf |