loading...| Preferred Name |
Deferoxamine Mesylate |
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| Synonyms |
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|
| Definitions |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C417 |
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| CAS_Registry |
138-14-7 |
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| CHEBI_ID |
CHEBI:31460 |
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| Chemical_Formula |
C25H48N6O8.CH4O3S |
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| code |
C417 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome. |
|
| Display_Name |
Deferoxamine Mesylate |
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| FDA_UNII_Code |
V9TKO7EO6K |
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| FULL_SYN |
Deferoxamine B Deferoxamine Methanesulfonate DEFEROXAMINE MESYLATE Deferoxamine mesylate Deferoxamine Mesylate Desferrioxamine Mesylate Deferrioxamine B DFM Desferal |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Deferoxamine Mesylate |
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| Legacy Concept Name |
Deferoxamine_Mesylate |
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| Maps_To |
Deferoxamine Mesylate |
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| NCI_Drug_Dictionary_ID |
41696 |
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| NSC Number |
644468 |
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| PDQ_Closed_Trial_Search_ID |
41696 |
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| PDQ_Open_Trial_Search_ID |
41696 |
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| Preferred_Name |
Deferoxamine Mesylate |
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| prefixIRI |
Thesaurus:C417 |
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| prefLabel |
Deferoxamine Mesylate |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0011148 |
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| 文本定义 |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome. |
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| subClassOf |