The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	nisoldipine
Synonyms	3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate C20H24N2O6
ID	http://purl.obolibrary.org/obo/dinto_DB00401
AHFScode	24:28.08
ATCCode	C08CA07
CASRN	63675-72-9
DBBrand	baymycard sular nisocor zadipina syscor
DBSynonym	nisoldipino [inn-spanish] nisoldipin nisoldipinum [inn-latin]
Definition	Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000447 http://purl.obolibrary.org/obo/OAE_0000424 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000207 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0000802 http://purl.obolibrary.org/obo/OAE_0000502 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000613 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0001742 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000329 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000405 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000313 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0001298 http://purl.obolibrary.org/obo/OAE_0000350 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027
InChI	InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChIKey	InChIKey=VKQFCGNPDRICFG-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027
is metabolised by	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
label	nisoldipine
may interact with	http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:dinto_DB00401
prefLabel	nisoldipine
SMILES	COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OCC(C)C
Synonym	3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate C20H24N2O6
xref	PubChem Compound:4499 Drugs.com:http://www.drugs.com/cdi/nisoldipine-extended-release-tablets.html ChemSpider:4343 RxList:http://www.rxlist.com/cgi/generic/nisoldipine.htm IUPHAR:2524 Guide To Pharmacology:2524 PharmGKB:PA450634 PubChem Substance:46504546 National Drug Code Directory:0677-1978-01 BindingDB:50011689 Wikipedia:http://en.wikipedia.org/wiki/Nisoldipine
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/XCO_0000658	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7577	CHEBI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148422	NDFRT	LOOM
http://purl.bioontology.org/ontology/RXNORM/7435	RXNORM	LOOM
http://purl.bioontology.org/ontology/NDDF/004175	NDDF	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018332	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/MESH_D015737	BERO	LOOM
http://purl.obolibrary.org/obo/NCIT_C29291	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015737	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_76917	FIDEO	LOOM
http://stirdf.jst.go.jp/id/200907069176544015	IOBC	LOOM
http://www.drugbank.ca/drugs/DB00401	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0028116	OCHV	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8727	OCHV	LOOM
http://purl.bioontology.org/ontology/RCD/blg..	RCD	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386861009	SNOMEDCT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148422	OCVDAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.203.580	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D015737	MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0016388	OMIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_7577	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7577	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7577	DRON	LOOM
https://go.drugbank.com/drugs/DB00401	MDM	LOOM
http://purl.bioontology.org/ontology/ATC/C08CA07	ATC	LOOM
http://purl.jp/bio/4/id/200906054046973266	IOBC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29291	NCIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4020942	VANDF	LOOM
http://www.co-ode.org/ontologies/galen#Nisoldipine	GALEN	LOOM