Preferred Name |
pergolide |
|
Synonyms |
(2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline pergolidum pergolide C19H26N2S pergolida |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_63617 |
|
activates |
http://purl.obolibrary.org/obo/dinto_4020 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_3475 http://purl.obolibrary.org/obo/dinto_4010 http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_2858 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_0656 http://purl.obolibrary.org/obo/dinto_0909 http://purl.obolibrary.org/obo/dinto_2705 http://purl.obolibrary.org/obo/dinto_1166 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_0648 http://purl.obolibrary.org/obo/dinto_0234 |
|
AHFScode |
28:36.20.04 |
|
altId |
CHEBI:8020 |
|
ATCCode |
N04BC02 |
|
CASRN |
66104-22-1 |
|
DBBrand |
permax |
|
DBname |
pergolide |
|
DBSynonym |
pergolidum [inn-latin] pergolide mesylate pergolide methanesulfonate pergolida [inn-spanish] |
|
Definition |
A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. |
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has pharmacological target | ||
has role | ||
InChI |
InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 |
|
InChIKey |
InChIKey=YEHCICAEULNIGD-MZMPZRCHSA-N |
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inhibits | ||
is metabolised by | ||
label |
pergolide |
|
prefixIRI |
obo2:CHEBI_63617 |
|
prefLabel |
pergolide |
|
SMILES |
[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CSC)CN2CCC [H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@@H](CSC)CN2CCC |
|
Synonym |
(2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline pergolidum pergolide C19H26N2S pergolida |
|
xref |
ChEMBL:112494 CiteXplore:11852289 Wikipedia:http://en.wikipedia.org/wiki/Pergolide Patent:US4166182 CASRN:66104-22-1 KEGG DRUG:D08339 Wikipedia:Pergolide National Drug Code Directory:0187-0839-01 CiteXplore:2012117 CiteXplore:15180134 PubChem Compound:47811 BindingDB:50017543 DrugBank:DB01186 PubChem Substance:46507604 CiteXplore:16845152 Drugs Product Database (DPD):2123320 CiteXplore:18071034 Drugs.com:http://www.drugs.com/cdi/pergolide-mesylate.html KEGG COMPOUND:C07425 Reaxys:5091461 RxList:http://www.rxlist.com/cgi/generic2/pergol.htm PharmGKB:PA450873 ChemSpider:43503 |
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subClassOf |