loading...| Preferred Name |
hemopoietic stem cell |
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| Synonyms |
blood forming stem cell hemopoietic stem cell colony forming unit hematopoietic HSC |
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| Definitions |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
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| ID |
http://purl.obolibrary.org/obo/CL_0000037 |
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| comment |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. |
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| ccf_ct_isa | ||
| ccf_located_in |
http://purl.obolibrary.org/obo/UBERON_0002371 http://purl.obolibrary.org/obo/UBERON_0001250 http://purl.obolibrary.org/obo/UBERON_0001266 |
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| ccf_pref_label |
hemopoietic stem cell hematopoetic stem cell |
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| database_cross_reference |
MESH:D006412 BTO:0000725 CALOHA:TS-0448 VHOG:0001485 FMA:70337 FMA:86475 |
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| definition |
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
|
| has exact synonym |
blood forming stem cell hemopoietic stem cell |
|
| has_related_synonym |
colony forming unit hematopoietic HSC |
|
| id |
CL:0000037 |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim |
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| isDefinedBy | ||
| label |
hematopoietic stem cell |
|
| notation |
CL:0000037 |
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| prefLabel |
hemopoietic stem cell Hematopoetic Stem Cell |
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| present_in_taxon | ||
| subClassOf |