Preferred Name |
Teniposide |
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Synonyms |
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|
Definitions |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04) |
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ID |
http://purl.obolibrary.org/obo/NCIT_C857 |
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ALT_DEFINITION |
An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors. |
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CAS_Registry |
29767-20-2 |
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Chemical_Formula |
C32H32O13S |
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code |
C857 |
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Contributing_Source |
CTRP FDA |
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definition |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04) |
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Display_Name |
Teniposide |
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FDA_UNII_Code |
957E6438QA |
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Has_Target | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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Is_Value_For_GDC_Property | ||
label |
Teniposide |
|
Legacy Concept Name |
Teniposide |
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Maps_To |
Teniposide |
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NCI_Drug_Dictionary_ID |
43671 |
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NSC Number |
122819 |
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PDQ_Closed_Trial_Search_ID |
43671 |
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PDQ_Open_Trial_Search_ID |
43671 |
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Preferred_Name |
Teniposide |
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prefixIRI |
NCIT:C857 |
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prefLabel |
Teniposide |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
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UMLS_CUI |
C0039512 |
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subClassOf |