loading...| Preferred Name |
Epipodophyllotoxin Compound |
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| Synonyms |
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| Definitions |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1331 |
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| ALT_DEFINITION |
A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor. |
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| code |
C1331 |
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| definition |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
|
| label |
Epipodophyllotoxin Compound |
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| Legacy Concept Name |
Epipodophyllotoxin_Compound |
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| Preferred_Name |
Epipodophyllotoxin Compound |
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| prefixIRI |
NCIT:C1331 |
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| prefLabel |
Epipodophyllotoxin Compound |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0086243 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | NCIT | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | ROO | LOOM |