loading...| Preferred Name |
Sunitinib |
|
| Synonyms |
|
|
| Definitions |
An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C71622 |
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| ALT_DEFINITION |
A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). Sunitinib is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor. |
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| CAS_Registry |
557795-19-4 |
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| CHEBI_ID |
CHEBI:38940 |
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| Chemical_Formula |
C22H27FN4O2 |
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| code |
C71622 |
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| Contributing_Source |
CTRP FDA |
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| definition |
An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. |
|
| Display_Name |
Sunitinib |
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| FDA_UNII_Code |
V99T50803M |
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| Has_Salt_Form | ||
| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C26203 http://purl.obolibrary.org/obo/NCIT_C18539 http://purl.obolibrary.org/obo/NCIT_C17328 http://purl.obolibrary.org/obo/NCIT_C26202 http://purl.obolibrary.org/obo/NCIT_C17975 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Sunitinib |
|
| Legacy Concept Name |
Sunitinib |
|
| Maps_To |
Sunitinib |
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| Preferred_Name |
Sunitinib |
|
| prefixIRI |
NCIT:C71622 |
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| prefLabel |
Sunitinib |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1176020 |
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| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C93259 |