loading...| Preferred Name |
Entacapone |
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| Synonyms |
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|
| Definitions |
A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61746 |
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| CAS_Registry |
130929-57-6 |
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| CHEBI_ID |
CHEBI:4798 |
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| Chemical_Formula |
C14H15N3O5 |
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| code |
C61746 |
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| Contributing_Source |
FDA |
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| definition |
A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier. |
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| FDA_UNII_Code |
4975G9NM6T |
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| in_subset | ||
| label |
Entacapone |
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| Legacy Concept Name |
Entacapone |
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| NCI_Drug_Dictionary_ID |
801668 |
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| PDQ_Closed_Trial_Search_ID |
801668 |
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| PDQ_Open_Trial_Search_ID |
801668 |
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| Preferred_Name |
Entacapone |
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| prefixIRI |
NCIT:C61746 |
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| prefLabel |
Entacapone |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0876730 |
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| subClassOf |