loading...| Preferred Name |
Propoxyphene, (+/-)- |
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| Synonyms |
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| Definitions |
A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61711 |
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| CAS_Registry |
2621-61-6 |
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| Chemical_Formula |
C22H29NO2 |
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| code |
C61711 |
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| Contributing_Source |
FDA |
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| definition |
A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. |
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| FDA_UNII_Code |
II2G62OV6F |
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| in_subset | ||
| label |
Propoxyphene, (+/-)- |
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| Legacy Concept Name |
DL-Propoxyphene |
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| Preferred_Name |
Propoxyphene, (+/-)- |
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| prefixIRI |
NCIT:C61711 |
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| prefLabel |
Propoxyphene, (+/-)- |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1880235 |
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| subClassOf |