Preferred Name |
Hydralazine Hydrochloride |
|
Synonyms |
|
|
Definitions |
The hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C551 |
|
CAS_Registry |
304-20-1 |
|
CHEBI_ID |
CHEBI:31672 |
|
Chemical_Formula |
C8H8N4.HCl |
|
code |
C551 |
|
Contributing_Source |
CTRP FDA |
|
definition |
The hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells. |
|
Display_Name |
Hydralazine Hydrochloride |
|
FDA_UNII_Code |
FD171B778Y |
|
Has_Free_Acid_Or_Base_Form | ||
Has_Target | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
Is_Value_For_GDC_Property | ||
label |
Hydralazine Hydrochloride |
|
Legacy Concept Name |
Hydralazine |
|
Maps_To |
Hydralazine Hydrochloride |
|
NCI_Drug_Dictionary_ID |
41835 |
|
NSC Number |
89394 |
|
PDQ_Closed_Trial_Search_ID |
41835 |
|
PDQ_Open_Trial_Search_ID |
41835 |
|
Preferred_Name |
Hydralazine Hydrochloride |
|
prefixIRI |
NCIT:C551 |
|
prefLabel |
Hydralazine Hydrochloride |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0699178 |
|
subClassOf |