Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Heparin
Synonyms
Definitions

A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots.
ID

http://purl.obolibrary.org/obo/NCIT_C539
Accepted_Therapeutic_Use_For

Conditions requiring anticoagulation (thrombosis; embolism)
ALT_DEFINITION

A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body and can also made in the laboratory. Heparin may be injected into muscle or blood to prevent or break up blood clots. It is a type of anticoagulant.
CAS_Registry

9005-49-6
CHEBI_ID

CHEBI:28304
Chemical_Formula

(C14H18NO11)n.2(C12H16NO13S)n.3HO3S
code

C539
Contributing_Source

CTRP

FDA
definition

A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots.
Display_Name

Heparin
FDA_UNII_Code

T2410KM04A
Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C833

http://purl.obolibrary.org/obo/NCIT_C1034

http://purl.obolibrary.org/obo/NCIT_C113690
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
label

Heparin
Legacy Concept Name

Heparin
NCI_Drug_Dictionary_ID

40848
PDQ_Closed_Trial_Search_ID

40848
PDQ_Open_Trial_Search_ID

40848
Preferred_Name

Heparin
prefixIRI

NCIT:C539
prefLabel

Heparin
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C2825026
subClassOf

http://purl.obolibrary.org/obo/NCIT_C263
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http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Heparin SEPON LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 EFO LOOM
http://purl.bioontology.org/ontology/LNC/LP15998-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006493 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/C05BA03 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146860 NDFRT LOOM
http://www.semanticweb.org/osnathakimi/ontologies/deb#Heparin DEB LOOM
http://purl.bioontology.org/ontology/SNMI/C-A6540 SNMI LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6003a365_2c74_422e_bb8d_08c54e2c1537 STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6003a365_2c74_422e_bb8d_08c54e2c1537 CVAO LOOM
http://stirdf.jst.go.jp/id/200907087372008154 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/015153 NDDF LOOM
https://go.drugbank.com/drugs/DB01109 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LA24058-2 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C539 NCIT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Heparin APAONTO LOOM
http://www.semanticweb.org/cjf/ontologies/2022/8/NeuralReprogrammingOntology(NRO)#heparin NRO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0019134 HFO LOOM
http://www.semanticweb.org/maria/ontologies/2023/1/OntologiaByMAF#OWLClass_7d0579c8_2473_40bb_a0c2_5a38a2da8e79 SP_ONTOLOGY LOOM
http://purl.bioontology.org/ontology/MESH/D006493 MESH LOOM
http://www.gamuts.net/entity#heparin GAMUTS LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.698.373.400 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB01109 FTC LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02152 MIO LOOM
http://www.co-ode.org/ontologies/galen#Heparin GALEN LOOM
http://www.semanticweb.org/ontologies/2008/8/MultiscaleSkinPhysiologyOntology.owl#Heparin SPO LOOM
http://bmi.utah.edu/ontologies/peontology/C0019134 PE LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003766 LOINC LOOM
http://purl.bioontology.org/ontology/ATC/B01AB01 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 IDOMAL LOOM
http://purl.obolibrary.org/obo/CHEBI_28304 IDODEN LOOM
http://bmi.utah.edu/ontologies/peontology/C0642228 PE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6030 OCHV LOOM
http://purl.org/obo/owlapi/fma#FMA_82839 BIOMODELS LOOM
http://localhost/plosthes.2017-1#1975 PLOSTHES LOOM
http://purl.bioontology.org/ontology/RCD/x005J RCD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372877000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/CSP/2378-9717 CRISP LOOM
http://purl.bioontology.org/ontology/ATC/S01XA14 ATC LOOM
http://www.semanticweb.org/ontologies/2010/10/BPO.owl#heparin BHO LOOM
http://purl.org/sig/ont/fma/fma82839 FMA LOOM
http://purl.obolibrary.org/obo/HINO_0009606 HINO LOOM
http://purl.bioontology.org/ontology/RXNORM/5224 RXNORM LOOM
http://purl.obolibrary.org/obo/OMIT_0007662 OMIT LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571352688529240153 ACVD_ONTOLOGY LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0019134 OCHV LOOM
http://www.pepathway.org/peo/1.2#heparin PE-O LOOM
http://purl.bioontology.org/ontology/VANDF/4018538 VANDF LOOM
http://purl.jp/bio/4/id/200906087873265331 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021012 PMAPP-PMO LOOM