loading...| Preferred Name |
Acridine |
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| Synonyms |
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| Definitions |
A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C203 |
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| CAS_Registry |
260-94-6 |
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| CHEBI_ID |
CHEBI:36420 |
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| code |
C203 |
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| Contributing_Source |
FDA |
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| definition |
A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death. |
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| FDA_UNII_Code |
42NI1P5Q1X |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Acridine |
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| Legacy Concept Name |
Acridine |
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| Maps_To |
Acridine |
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| Preferred_Name |
Acridine |
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| prefixIRI |
NCIT:C203 |
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| prefLabel |
Acridine |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0001186 |
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| subClassOf |