loading...| Preferred Name |
Idarubicin Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1587 |
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| Accepted_Therapeutic_Use_For |
In combination therapies for acute myelogenous leukemia and pediatric acute lymphocytic leukemia. |
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| CAS_Registry |
57852-57-0 |
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| Chemical_Formula |
C26H27NO9.HCl |
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| code |
C1587 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds |
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| Display_Name |
Idarubicin Hydrochloride |
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| FDA_UNII_Code |
5VV3MDU5IE |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Idarubicin Hydrochloride |
|
| Legacy Concept Name |
Idarubicin_Hydrochloride |
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| Maps_To |
Idarubicin Hydrochloride |
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| NCI_Drug_Dictionary_ID |
39753 |
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| NSC Number |
256439 |
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| PDQ_Closed_Trial_Search_ID |
39753 |
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| PDQ_Open_Trial_Search_ID |
39753 |
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| Preferred_Name |
Idarubicin Hydrochloride |
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| prefixIRI |
NCIT:C1587 |
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| prefLabel |
Idarubicin Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0939353 |
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| subClassOf |