Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Anthracycline Antineoplastic Antibiotic
Synonyms
Definitions

An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
ID

http://purl.obolibrary.org/obo/NCIT_C1594
ALT_DEFINITION

A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.
CHEBI_ID

CHEBI:49322
code

C1594
Contributing_Source

CTRP
definition

An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
Display_Name

Anthracycline Antineoplastic Antibiotic
Has_Target

http://purl.obolibrary.org/obo/NCIT_C17766
in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
label

Anthracycline Antineoplastic Antibiotic
Legacy Concept Name

Anthracycline_Antibiotic
Preferred_Name

Anthracycline Antineoplastic Antibiotic
prefixIRI

NCIT:C1594
prefLabel

Anthracycline Antineoplastic Antibiotic
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C0282564
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2115

http://purl.obolibrary.org/obo/NCIT_C259

http://purl.obolibrary.org/obo/NCIT_C1968
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