loading...| Preferred Name |
Daunorubicin Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1583 |
|
| Accepted_Therapeutic_Use_For |
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia |
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| ALT_DEFINITION |
A drug used to treat acute leukemias and some other types of cancer. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Cerubidine is a type of anthracycline antibiotic and a type of topoisomerase inhibitor. |
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| CAS_Registry |
23541-50-6 |
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| Chemical_Formula |
C27H29NO10.HCl |
|
| code |
C1583 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. |
|
| Display_Name |
Daunorubicin Hydrochloride |
|
| FDA_UNII_Code |
UD984I04LZ |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Daunorubicin Hydrochloride |
|
| Legacy Concept Name |
Daunomycin |
|
| Maps_To |
Daunorubicin Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
39779 |
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| NSC Number |
82151 83142 |
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| PDQ_Closed_Trial_Search_ID |
39779 |
|
| PDQ_Open_Trial_Search_ID |
39779 |
|
| Preferred_Name |
Daunorubicin Hydrochloride |
|
| prefixIRI |
NCIT:C1583 |
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| prefLabel |
Daunorubicin Hydrochloride |
|
| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0282123 |
|
| subClassOf |