loading...| Preferred Name |
Paclitaxel |
|
| Synonyms |
|
|
| Definitions |
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1411 |
|
| Accepted_Therapeutic_Use_For |
AIDS-related Kaposi's sarcoma; Bladder cancer; Breast cancer; Cervical cancer; Endometrial adenocarcinoma; Esophageal cancer; Head and Neck cancer; Lung cancer; non-small cell; Lymphoma; Ovarian cancer; Prostate cancer; Testicular cancer |
|
| ALT_DEFINITION |
A drug used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used together with another drug to treat non-small cell lung cancer. Paclitaxel is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent. |
|
| CAS_Registry |
33069-62-4 |
|
| CHEBI_ID |
CHEBI:45863 |
|
| Chemical_Formula |
C47H51NO14 |
|
| code |
C1411 |
|
| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04) |
|
| Display_Name |
Paclitaxel |
|
| FDA_UNII_Code |
P88XT4IS4D |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C157711 |
|
| Is_PCDC_GCT_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Paclitaxel |
|
| Legacy Concept Name |
Paclitaxel |
|
| Maps_To |
Paclitaxel |
|
| NCI_Drug_Dictionary_ID |
39762 |
|
| NSC Number |
125973 673089 |
|
| PDQ_Closed_Trial_Search_ID |
39762 |
|
| PDQ_Open_Trial_Search_ID |
39762 |
|
| Preferred_Name |
Paclitaxel |
|
| prefixIRI |
NCIT:C1411 |
|
| prefLabel |
Paclitaxel |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0144576 |
|
| subClassOf |