loading...| Preferred Name |
Fludarabine |
|
| Synonyms |
|
|
| Definitions |
A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1094 |
|
| Accepted_Therapeutic_Use_For |
Acute nonlymphocytic leukemia; Chronic lymphocytic leukemia; Indolent Non - Hodkins Lymphoma |
|
| ALT_DEFINITION |
The active ingredient in a drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. Fludarabine blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor. |
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| CAS_Registry |
21679-14-1 |
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| Chemical_Formula |
C10H12FN5O4 |
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| code |
C1094 |
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| Contributing_Source |
FDA PCDC |
|
| definition |
A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. (NCI04) |
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| FDA_UNII_Code |
P2K93U8740 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Fludarabine |
|
| Legacy Concept Name |
Fludarabine |
|
| Maps_To |
Fludarabine |
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| NSC Number |
118218 |
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| Preferred_Name |
Fludarabine |
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| prefixIRI |
NCIT:C1094 |
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| prefLabel |
Fludarabine |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
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| UMLS_CUI |
C0059985 |
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| subClassOf |