loading...| Preferred Name |
aminoglycoside antibiotic |
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| Synonyms |
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| Definitions |
Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. |
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| ID |
http://purl.obolibrary.org/obo/ARO_0000016 |
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| definition |
Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. |
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| has_obo_namespace |
antibiotic_resistance |
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| id |
ARO:0000016 |
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| label |
aminoglycoside antibiotic |
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| notation |
ARO:0000016 |
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| prefLabel |
aminoglycoside antibiotic |
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| subClassOf |