loading...| Preferred Name | Clozapine | |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass932c0f47_bb57_4af6_8363_b1a0865e0abc |
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| Chinese |
氯氮平 |
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| MESH_Definition |
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
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| NCIt_Definition |
A synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04) |
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| prefLabel |
Clozapine |
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| Synonyms |
Clozapina cloZAPine 5H-Dibenzo(be)(14)diazepine 8-chloro-11-(4-methyl-1-piperazinyl)- CLOZAPINE (SANDOZ) Clozapine (substance) Clozapinum CLOZAPINE (MAYNE) Product containing clozapine (medicinal product) Clozapin 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(be)(14)diazepine Clozapine-containing product CLOZAPINE (GOLDEN STATE) |
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