loading...| Preferred Name | Glucocorticoid | |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass030a612b_ccf9_44ea_b206_fd8015d32cc7 |
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| Chinese |
糖皮质激素 |
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| MESH_Definition |
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. |
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| NCIt_Definition |
A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic, and homeostatic functions, and which binds specifically to the glucocorticoid receptor (GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid response elements (GRE) and regulates the expression of GR-responsive genes. |
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| prefLabel |
Glucocorticoid |
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| Synonyms |
Product containing glucocorticoid (product) glucocorticoid Glucocorticoid hormone Glucocorticoid (substance) glucocorticoids Glucocorticoid hormone (substance) Glucocorticoid-containing product |
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