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Radiation Oncology Ontology
Last uploaded:
June 19, 2018
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| Preferred Name | Mitomycin | |
| Synonyms |
Mitomycin-C |
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| Definitions |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1820 |
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| altLabel |
Mitomycin-C
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| definition |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.
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| isDefinedBy | ||
| label |
Mitomycin
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| prefixIRI |
ncit:C1820
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| prefLabel |
Mitomycin
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| subClassOf |
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